[Circadian rhythm variability in arterial blood pressure]. / Variabilidad circadiana de la presión arterial.

Summary Chrono-biology consists of the scientific study of biological rhythms and their underlying mechanisms. This study is based on the certainty that for many physiological variables these exists a reproducible pattern in the time of maximum and minimum values. The study of circadian rhythm variations on biological parameters which affect numerous pathologies permits one to foresee rhythmical cycles and to synchronize pharmacological rules to make it possible to obtain improvements in patients' responses. Knowing the circadian rhythm in hypertensive patients brings data related to the prognosis and is a basic tool to introduce the concept of a chronological administration of medicines in providing antihypertensive treatment; this is chronotherapy.

Variabilidad cotidiana de la presión arterial / Circadian rhythm variability in arterial blood pressures

La cronobiología consiste en el estudio cientffico de los ritmos biológicos y sus mecanismos subyacentes. Este estudio se fundamenta en la constatación de que, para muchas variables fisiológicas, existe un patrón reproducible en el tiempo de valores máximos y mínimos. El estudio de las variaciones circadianas de los parámetros biológicos que afectan a numerosas patologlas, permite prever los ritmos cíclicos y sincronizar las pautas farmacológicas con el fin de obtener una mejora de las respuestas en los pacientes. El conocimiento del perfil circadiano de los pacientes hipertensos aporta datos relacionados con el pronóstico, y es una herramienta básica para introducir en el tratamiento antihipertensivo el concepto de la administración temporalizada de los medicamentos, esto es, la cronoterapia

Chrono-biology consists of the scientific study of biolqgical rhythms and their underlying mechanisms. This study is based on the certainty that for many physiological variables these exists a reproducible pattern in the time of maximum and minimum values. The study of circadian rhythm variations on biological parameters which affect numerous pathologies permits one to foresee rhythmical cycles and to synchronize pharmacological rules to make it possible to obtain improvements in patients' responses. Knowing the circadian rhythm in hypertensive patients brings "data related to the prognosis and is a basic tool to introduce the concept of a chronological administration of medicines in providing antihypertensive treatment; this is chronotherapy